Nevirapine (Viramune) is an antiretroviral prescription medication that is used for treating HIV and AIDS.
Binds directly to reverse transcriptase and blocks RNA, DNA, causing a disruption of the enzyme’s site.
HIV-1 in combination with other highly active antiretroviral treatments (HAART).
Nevirapine given with warfarin resulted in decreased warfarin action.
Dosage and Routes
Available in Tablets 200 mg, Oral suspension 50 mg / 5 ml.
– Adult PO 200 mg qd x 2 wks, then 200 mg bid in combination.
– Child >8 yo PO 4 mg / kg / qd x 2 wks, then 4 mg / kg / bid.
– Child <8 yo PO 4 mg / kg / qd x 2 wks, then 7 mg / kg / bid.
Side effects , Adverse reactions
Diarrhea, abdominal pain, nausea, stomatitis, hepatotoxicity.
Paresthesia, headache, fever, peripheral neuropathy.
Rash, toxic epidermal necrolysis
Neutropenia, anemia, thrombocytopenia.
Hepatic disease, pregnancy, lactation, children, renal disease.
Do not confuse
– Sign of infection; anemia.
– Allergies before treatment and reaction to each medication; if rash is severe or systemic symptoms occur, discontinue immediately.
– Bowel pattern before, during treatment; if severe abdominal pain with bleeding occurs, drug should discontinued; monitor hydration.
Without regard to meals
Teach patient / family
– To report any right quadrant pain, jaundice, rash immediately;
– That drug may be taken without food, antacids, didanosine;
– Take as prescribed; if missed, take as soon as remembered up to one hour before the next dose; do not double dose.
– That drug is not a cure, controls symptoms of HIV.