What is Viramune and its uses?

Nevirapine (Viramune) is an antiretroviral prescription medication that is used for treating HIV and AIDS.

Action

Binds directly to reverse transcriptase and blocks RNA, DNA, causing a disruption of the enzyme’s site.

Uses

HIV-1 in combination with other highly active antiretroviral treatments (HAART).

Research Note

Nevirapine given with warfarin resulted in decreased warfarin action.

Dosage and Routes

Available in Tablets 200 mg, Oral suspension 50 mg / 5 ml.

– Adult PO 200 mg qd x 2 wks, then 200 mg bid in combination.
– Child >8 yo PO 4 mg / kg / qd x 2 wks, then 4 mg / kg / bid.
– Child <8 yo PO 4 mg / kg / qd x 2 wks, then 7 mg / kg / bid.

Side effects , Adverse reactions

GI

Diarrhea, abdominal pain, nausea, stomatitis, hepatotoxicity.

CNS

Paresthesia, headache, fever, peripheral neuropathy.

INTEG

Rash, toxic epidermal necrolysis

MS

Pain, myalgia

HEMA

Neutropenia, anemia, thrombocytopenia.

MISC

Stevens-Johnson syndrome

Contraindications

Hypersensitivity

Precautions

Hepatic disease, pregnancy, lactation, children, renal disease.

Do not confuse

nevirapine/nelfinavir

viramune/viracept

Nursing Considerations

– Sign of infection; anemia.

– Allergies before treatment and reaction to each medication; if rash is severe or systemic symptoms occur, discontinue immediately.

– Bowel pattern before, during treatment; if severe abdominal pain with bleeding occurs, drug should discontinued; monitor hydration.

Administration

Without regard to meals

Teach patient / family

– To report any right quadrant pain, jaundice, rash immediately;

– That drug may be taken without food, antacids, didanosine;

– Take as prescribed; if missed, take as soon as remembered up to one hour before the next dose; do not double dose.

– That drug is not a cure, controls symptoms of HIV.

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